National Cancer Institute   U.S. National Institutes of Health |
Clinical Trials Support Unit Oncology Patient Enrollment Network


Due to system maintenance, OPEN will be unavailable on Thursday, September 3rd between 8:00 PM to 10:00 PM EST. We apologize for any inconvenience this may cause.

Welcome to the Oncology Patient Enrollment Network (OPEN) Portal system

OPEN is the web-based registration system for patient enrollments onto NCI-sponsored Network Group clinical trials. The system is integrated with the CTSU Enterprise System for regulatory and roster data, and with each of the Network Groups' registration/randomization systems for patient registration/ randomization. OPEN provides the ability to enroll patients on a 24/7 basis.

PDF Logo Training and Demonstration Materials:

  • User Guide »This users guide has a linkable Table of Contents that will bring you to any topic you choose, or you can scroll through and/or print the entire guide.
  • OPEN Demo Video »The OPEN training video has been updated and reformatted. Click on one of the tabs at the top of the screen for a drop down list of instructional topics, then click on the specific topic you want to view.
  • Frequently Asked Questions (FAQ) »Frequently asked questions about OPEN Portal.
  • Access & Crediting Guidelines »Guidelines for OPEN Portal Access and Crediting.
  • Slot Reservation Quick User Guide »This user guide is a quick reference intended to assist you with the process of reserving a slot for a patient on protocols that use the slot reservation system.

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